The Predictive Brain Lab is based at the Centre for Cognitive Neuroimaging at the Donders Institute in Nijmegen, Netherlands.
The lab is headed by Dr. Floris de Lange.

Perception and decision-making are not automatic processes, but strongly shaped by internal brain states, which incorporate our goals, expectations, and knowledge about the world. The mechanisms by which these “top-down factors” affect perception, cognition, and behavior are still largely unknown. Where do the neuronal top-down signals come from? How do they change communication between sensory and decision-related brain regions? And how do these factors affect our perception and decision-making? These questions are the focus of investigation of the Predictive Brain Lab. We use a combination of behavioural and neuroimaging methods (MEG, fMRI, TMS) in healthy volunteers and clinical populations to examine how percepts and decisions are shaped by what we expect and deem relevant.

Recent key publications

  • Fritsche M, Mostert P, de Lange FP (2017). Opposite Effects of Recent History on Perception and Decision. Current Biology, 27, 1-6. pdf
  • Ekman M, Kok P, de Lange FP (2017). Time-compressed preplay of anticipated events in human primary visual cortex. Nature Communications, 8:15276. pdf
  • Roelfsema PR, de Lange FP (2016). Early visual cortex as a multi-scale cognitive blackboard. Annual Reviews in Vision Science 2: 131-151. pdf
  • Kok P, Bains LJ, van Mourik T, Norris DG & de Lange FP (2016). Selective activation of the deep layers of the human primary visual cortex by top-down feedback. Current Biology, 26, 371-376. pdf
  • Summerfield C, de Lange FP (2014). Expectation in perceptual decision-making: neural and computational mechanisms. Nature Reviews Neuroscience, 15, 745-56. pdf


  • Paper accepted in NeuroImage Albers AM, Meindertsma T, Toni I, de Lange FP (2017). Decoupling of BOLD amplitude and pattern classification of orientation-selective activity in human visual cortex. NeuroImage, in press.
    Posted by Floris de Lange
  • Paper accepted in Scientific Reports Utzerath C, St John Saaltink E, Buitelaar J, de Lange FP (2017). Repetition suppression to objects is modulated by stimulus-specific expectations. Scientific Reports, 8;7(1):8781. pdf
    Posted Aug 21, 2017, 1:45 AM by Floris de Lange
  • Paper accepted in PNAS Kok P, Mostert P, de Lange FP (2017). Prior expectations induce pre-stimulus sensory templates. Proceedings of the National Academy of Sciences, in press.
    Posted Aug 18, 2017, 2:43 AM by Floris de Lange
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